Botryoid odontogenic cyst: A case report with immunohistochemical aspects

We present a case of botryoid odontogenic cyst, affecting the anterior mandible in a 59-year-old Japanese female patient. The histochemical and immunohistochemical characteristics of the lesion are described. The nature of the cyst-lining epithelium was suggestive of an odontogenic origin as revealed by the expression of CK 10/13, CK14, and CK19, all of which have been reported to be present in the human enamel organ. An insignificant PCNA-immunoreaction was observed in the cyst-lining epithelium as compared with that of the odontogenic keratocyst. Furthermore, the appearance of diastase digestible, PAS-reactive material (consistent with glycogen) was evaluated that prefunctional cells of the dental lamina are a possible origin of the lesion.