ArtTitle>Solitary Neurofibroma of the Mandible

Central neurofibroma of the mandible is a rare tumour. This report is of a 21-year-old Japanese man with a symptomatic solitary neurofibroma of the left mandible. The tumour was excised with preservation of the mandibular nerve. The tumour consisted of proliferated dense collagen fibres and scattered spindle cells without mitotic figures or atypism. Immunohistochemistry showed that tumour cells were positive for vimentin, S100 protein, neurone specific enolase, and glial fibrillary acidic protein, but negative for desmin and α-smooth muscle actin. The diagnosis of neurofibroma was distinguished from a desmoplastic fibroma by the immunohistochemical findings.