کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3142379 1196782 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recurrence rate and shift in histopathological differentiation of oral squamous cell carcinoma – A long-term retrospective study over a period of 13.5 years
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Recurrence rate and shift in histopathological differentiation of oral squamous cell carcinoma – A long-term retrospective study over a period of 13.5 years
چکیده انگلیسی

ObjectiveLittle information is available as to whether recurrences of oral squamous cell carcinoma (OSCC) show different histopathological grades than the primary tumor and whether postoperative radiotherapy (PORT) influences the grade of differentiation in the case of recurrence. The objective of this study was the evaluation of recurrence rates and change in differentiation.Material and methodsThis retrospective, single-institution cohort study included surgically treated OSCC patients over a 13-year period (2000–2013). The relationship among tumor size, lymph node metastases, and recurrence rate of OSCC was investigated. Primary tumor differentiation was compared with differentiation of recurrence.ResultsA total of 429 patients (277 men and 152 women) were included in this study. Of these, 124 (28.9%) received PORT. The incidence of primary cervical metastases increased significantly with tumor size (p < 0.001). Recurrence developed in 82 patients (19.1%). Stage T1/T2 showed a significantly lower recurrence rate than stage T3/T4 (16.3% vs. 30.2%) (p < 0.01). A total of 23 (30.7%) patients with recurrence showed a change in differentiation.ConclusionIncreasing primary tumor size correlates with incidence of cervical metastases and recurrence rate. Initial cervical metastases show no effect on recurrence rates. Differentiation of primary tumor does not correlate with the recurrence rate. The majority of recurrences show consistent histopathological grading.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cranio-Maxillofacial Surgery - Volume 43, Issue 7, September 2015, Pages 1309–1313
نویسندگان
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