کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3142409 1196783 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of bone marrow-derived stem cells and bone morphogenetic protein-2 on treatment of osteoradionecrosis in a rat model
ترجمه فارسی عنوان
اثر سلول های بنیادی استخوانی مغز استخوان و پروتئین مورفوژنیک استخوان 2 در درمان استئورداریونکروز در یک مدل موش
کلمات کلیدی
سلول بنیادی استخوانی مغز استخوان، استخوان مورفوژنیک پروتئین-2، استئوآرادیونیکروز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی

PurposeWe investigated the effect of rat mesenchymal stem cells (rMSCs) and bone morphogenetic protein-2 (BMP-2) on the osseous healing of osteoradionecrosis in the rat mandible, depending on application time.Material and methodsOne week after irradiation (30 Gy) on the right mandible, all molar teeth were extracted. In Group 1 (n = 25), rMSCs and/or BMP-2 carried with hydrogel were applied immediately after surgery. In Group 2 (n = 25), application was done 4 weeks after surgery, after the occurrence of osteoradionecrosis. No hydrogel (n = 5), hydrogel alone (n = 5), hydrogel with 2 × 104 rMSCs (n = 5), hydrogel with 10 μg of BMP-2 (n = 5), or hydrogel with 10 μg of BMP-2 and 2 × 104 rMSCs (n = 5) was applied. Micro-CT data of bone healing were collected at 4 weeks post-application.ResultsIn Group 1, BMP-2 was effective in increasing both bone volume (BV) and bone mineral density (BMD), whereas rMSCs were not. In Group 2, the combined application of rMSCs and BMP-2 significantly increased BMD and BV compared to values in the groups without hydrogel and with hydrogel alone.ConclusionOsseous healing after post-irradiation trauma in rats was enhanced immediately after dentoalveolar trauma by application of BMP-2, whereas the combined application of rMSCs and BMP-2 was most effective after osteoradionecrosis occurred.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cranio-Maxillofacial Surgery - Volume 43, Issue 8, October 2015, Pages 1478–1486
نویسندگان
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