Anesthetic Efficacy of Combinations of 0.5 mol/L Mannitol and Lidocaine with Epinephrine for Inferior Alveolar Nerve Blocks in Patients with Symptomatic Irreversible Pulpitis

For mandibular posterior teeth in patients with symptomatic irreversible pulpitis, the addition of 0.5 mol/L mannitol to 1.9 mL of lidocaine (76.4 mg) with epinephrine resulted in a statistically higher success rate. However, the combination lidocaine/mannitol formulation would not result in predictable pulpal anesthesia.