کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3149910 1197485 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of Root Canal Sealers on Lipopolysaccharide-induced Expression of Cyclooxygenase-2 mRNA in Murine Macrophage Cells
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Effects of Root Canal Sealers on Lipopolysaccharide-induced Expression of Cyclooxygenase-2 mRNA in Murine Macrophage Cells
چکیده انگلیسی
Cyclooxygenase-2 (COX-2) is a useful biomarker of the inflammatory potential of biomaterials in vitro. In this study we investigate the effects of soluble extracts from 3 selected root canal sealers (AH26, Sealapex, and N2 Universal) on COX-2 mRNA expression in cultured murine macrophage cells. Root canal sealers and the addition of lipopolysaccharide (LPS) both produced significant increases in COX-2 mRNA expression in RAW 264.7 macrophages. In addition, both Sealapex and N2 Universal produced a synergistic 6- to 8-fold increase in COX-2 mRNA expression, whereas AH26 did not demonstrate synergy with LPS. These results suggest that LPS and certain root canal sealers have a synergistic effect on the inflammatory responses of macrophages. Under the conditions of this in vitro study, the results suggest that one potential mechanism of periapical inflammatory reactions might be the synergistic effects of certain root canal sealers on LPS-induced COX-2 expression by macrophage cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Endodontics - Volume 33, Issue 11, November 2007, Pages 1329-1333
نویسندگان
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