Action of Nicotine and Ovariectomy on Bone Regeneration After Tooth Extraction in Rats

PurposeThe purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.Materials and MethodsFor 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on days 7 and 14 when the alveoli were removed for further analyses.ResultsThe data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.ConclusionThese results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy.