The Relationship Between IL-1 Gene Polymorphism and Marginal Bone Loss Around Dental Implants

PurposeEarly marginal bone loss around dental implants has been found during the bone healing period before stage II surgery despite a lack of apparent cause, and the etiology of this bone loss is unclear. This study was designed to investigate whether interleukin-1 gene polymorphism is associated with the marginal bone loss around the implants before stage II.Materials and MethodsOne hundred forty-three implants were placed in 59 patients. The patients were divided into 2 groups: 1) test group: with 1 or more marginal bone loss greater than 0.5 mm; and 2) control group: with marginal bone resorption less than 0.5 mm. Polymorphisms of the IL-1α and IL-1β genes (IL-1A−889, IL-1B−511, and IL-1B+3954) were detected by restriction fragment length polymorphism using Ncol, AvaI, and TaqI digestion after polymerase chain reactions.ResultsThe frequency of IL-1B−511 II/II was significantly higher among patients in early marginal bone loss (+) group than those in early marginal bone loss (−) group (P < .05). Multiple logistic regressions showed the OR of the II/II versus the I/I+I/II of the IL-1B−511 genotype was 3.933 between the 2 groups. The difference was statistically significant (P < .05). There was no significant difference between the other risk factors.ConclusionThese results suggest that the IL-1B−511 II/II genotype in individuals is associated with early marginal bone loss around implants.