Recombinant Human BMP-2 Enhances the Effects of Materials Used for Reconstruction of Large Cranial Defects

The addition of rhBMP-2 to demineralized bone matrix accelerated new bone formation in large cranial defects, regardless of the supporting framework or the addition of platelet-rich plasma. The use of a resorbable mesh in such defects is advisable only if rhBMP-2 is added.