کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3161590 1198607 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Severe cutaneous adverse drug reactions
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
Severe cutaneous adverse drug reactions
چکیده انگلیسی

Severe cutaneous drug reactions are one of the commonest medical challenges presenting to an emergency room in any hospital. The manifestations range from maculopapular rash to severe systemic symptoms like renal failure and cardiovascular compromise. Toxic epidermal necrolysis, erythroderma, drug rash with eosinophilia and systemic symptoms, acute generalised exanthematous pustulosis and drug induced vasculitis are the common cutaneous drug reactions which can have severe morbidity and even mortality. Careful history taking of the lag period after drug intake and associated symptoms, along with detailed examination of the skin, mucosa and various systems, help in early diagnosis of these reactions. Early stoppage of the incriminating drug, specific therapy including corticosteroids, cyclosporine and intravenous immunoglobulin depending on the case along with supportive therapy and local measures help in salvaging most patients. An overview of these important cutaneous drug reactions along with their management is being reviewed in this article.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Journal Armed Forces India - Volume 69, Issue 4, October 2013, Pages 375–383
نویسندگان
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