کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
316285 537711 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The analysis of BDNF gene polymorphism haplotypes and impulsivity in methamphetamine abusers
چکیده انگلیسی

An increasing number of evidence showed that genetic factors might contribute to drug abuse vulnerability. Data from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be associated with substance abuse or dependence. To test the hypothesis that the BDNF gene polymorphism is involved in methamphetamine abuse, we compared three single nucleotide polymorphisms (SNPs, rs16917204, rs16917234, and rs2030324) of the BDNF gene in 200 methamphetamine abusers and 219 healthy individuals. We also considered the association of these polymorphisms with impulsivity in methamphetamine abusers using Barratt Impulsivity Scale-11(BIS-11) Chinese version. Individual SNP analysis showed no significant differences in genotype and allele distributions between the methamphetamine abusers and controls. Haplotype analysis of rs16917204–rs16917234–rs2030324 revealed that a major C–C–T haplotype was significantly associated a lower odds of methamphetamine abuse, even after Bonferroni correction. Within the methamphetamine-abuse group, subjects carrying the T allele of rs2030324 genotype had significantly higher motor impulsivity scores of BIS compared to those with the C/C genotype. Our findings suggest that the BDNF gene polymorphism may contribute to the impulsivity in methamphetamine abusers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comprehensive Psychiatry - Volume 59, May 2015, Pages 62–67
نویسندگان
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