کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3212690 1203192 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cutaneous microbiome studies in the times of affordable sequencing
ترجمه فارسی عنوان
مطالعات میکروبیومی پوستی در زمان توالی مقرون به صرفه
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی


• Advances in DNA sequencing methodology, analysis and affordability led to breakthroughs in defining cutaneous microbiomes.
• Actinobacteria, Firmicytes, Proteobacteria and Bacteroidetes dominate skin bacterial, Malassezia the fungal microbiota.
• There is remarkable interpersonal variation, changes over time and body site specificities in skin microbiota.
• Commensals protect from pathogens and activate the immune system, which can lead to probiotics approaches in prevention.
• Psoriatic and eczematous skin have altered microbial arrays; unexpectedly, the microbe diversity is reduced in psoriatics.

BackgroundSkin is our first line of defense against pathogenic microorganisms and the intimate contact between the epidermis and microbes has been well known.PurposesMicrobes that cause infection are associated with inflammatory dermatoses and exacerbate wound healing. It is therefore of vital importance to understand the intricacies of skin-microbiota interactions. However, until recently our knowledge and understanding was limited by being unable to deal with uncultivatable microorganisms, which constitute a large majority.Basic proceduresRecent advances in DNA sequencing methodologies, analysis tools and affordability led to major breakthroughs in defining the cutaneous microbiome.Main findingsWe now know that four phyla, Actinobacteria, Firmicytes, Proteobacteria and Bacteroidetes, constitute preponderance of skin bacteria, while Malassezia dominates the fungal microbiome. We know that there are some 300 different bacteria inhabiting our skin. We also know that there is remarkable interpersonal variation, that the microbiota change over time, that different body sites harbor specific microbial arrays and that microbiota characteristically change in skin diseases.Principal conclusionsThe recent advances led to appreciation that microbes are, for the most part, our allies, useful and protective, and that with increased understanding we will be able to harness our cutaneous friends to maintain and promote our health.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 75, Issue 2, August 2014, Pages 82–87
نویسندگان
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