کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3212763 1203197 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mammalian target of rapamycin and tuberous sclerosis complex
ترجمه فارسی عنوان
هدف پستانداران رامامایسین و پیچیدگی اسکلروز سلولی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
چکیده انگلیسی


• Mammalian target of rapamycin (mTOR) is an evolutionally conserved protein kinase and is an essential regulator of a wide range of functions.
• The pathway is involved in cell viability, growth, autophagy, cellular senescence and immune reactions.
• Impairment in the regulation of mTOR causes many diseases.
• Much attention has been paid to mTOR as an essential cause of diseases and a therapeutic target.
• mTORC1 inhibitors are effective on the treatment of TSC, a representative disease that causes mTORC1 hyperactivity.

Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that is a member of the phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family. mTOR forms two distinct complexes, mTORC1 and mTORC2. mTORC1 has emerged as a central regulator of cellular metabolism, cell proliferation, cellular differentiation, autophagy and immune response regulation. In contrast to mTORC1, mTORC2, which is not well understood, participates in cell survival and the regulation of actin and cytokeratin organization. In addition, mTORC1 has been implicated in many diseases, including cancer, metabolic diseases, neurological disease, genetic diseases and longevity/aging.One of the diseases resulting from dysfunction of mTORC1 is tuberous sclerosis complex (TSC), which reflects all the symptoms that arise in response to mTORC1 dysfunction. TSC is a multiple hamartomas syndrome with epilepsy, autism, mental retardation and hypopigmented macules that are caused by the constitutive activation of mTORC1 resulting from genetic mutation of TSC1 or TSC2. Inhibitors of mTORC1, such as rapamycin, effectively suppress the symptoms of TSC.This article summarizes the current knowledge on mTOR and the efficacy of mTORC1 inhibitors in the treatment of TSC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science - Volume 79, Issue 2, August 2015, Pages 93–100
نویسندگان
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