Management of Beta-Adrenergic Blocker Poisoning

Beta-adrenergic blocking agents or β-blockers are prescribed for the treatment of a broad array of common disorders. Their widespread use, coupled with a narrow therapeutic index, contributes to their being a significant cause of poisoning from overdose and the second most common cause of mortality from cardiovascular agents. This article provides an overview of beta-adrenergic system pathophysiology and the properties and pharmacokinetics of β-blockers. Also discussed are the various effects and management of β-blockers in overdose settings.