کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3237782 1205687 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatitis C treatment and SVR: the gap between clinical trials and real-world treatment aspirations
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
پیش نمایش صفحه اول مقاله
Hepatitis C treatment and SVR: the gap between clinical trials and real-world treatment aspirations
چکیده انگلیسی

ObjectiveDespite the remarkable improvements in pharmacologic treatment efficacy for hepatitis C (HCV) reported in published clinical trials, published research suggests that, in “real-world” patient care, these medical outcomes may be difficult to achieve. This review was undertaken to summarize recent experience in the treatment of HCV in clinical settings, examining the course of patients through the stages of treatment and barriers to treatment encountered.MethodA comprehensive and representative review of the relevant literature was undertaken to examine HCV treatment experience outside of clinical trials in the last decade. This review found 25 unique studies with data on course of treatment and/or barriers to treatment in samples of patients with HCV not preselected for inclusion in clinical trials.ResultsResults were examined separately for samples selected for HCV infection versus HCV/HIV coinfection. Only 19% of HCV-selected and 16% of HCV/HIV-coinfection selected patients were considered treatment eligible and advanced to treatment; even fewer completed treatment (13% and 11%, respectively) or achieved sustained virologic response (3% and 6%, respectively). Psychiatric and medical ineligibilities were the primary treatment barriers.ConclusionOnly by systematically observing and addressing potentially solvable medical and psychosocial barriers to treatment will more patients be enrolled in and complete HCV therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General Hospital Psychiatry - Volume 35, Issue 2, March–April 2013, Pages 122–128
نویسندگان
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