کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3238686 1205973 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of induced hypertension on neurological outcome in forebrain ischaemia model in rats
ترجمه فارسی عنوان
تأثیر فشار خون ناشی بر پیامدهای عصبی در مدل ایسکمی پیشابراه در موش صحرایی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب اورژانس
چکیده انگلیسی

IntroductionThe present study investigated the effects of induced hypertension on hippocampal cell death after forebrain ischaemia in rats.Materials and methodsIn this study, forebrain ischaemia was induced in 20 Sprague-Dawley rats by clamping the bilateral common carotid arteries to induce systemic hypotension for 8 min. All rats then underwent reperfusion during which the induced hypertension group (n = 10) received intermittent intravenous injections of phenylephrine (5 μg) to maintain their mean arterial blood pressure at 20 mmHg above baseline for 10 min and the control group (n = 10) did not receive any treatment. In both groups, the numbers of viable and apoptotic neuronal cells in the cornu ammonis 1 (CA1) area of the hippocampus were evaluated 7 days after the induction of ischaemia.ResultsThe mean percentage of viable neuronal cells was higher in the induced hypertension group than in the control group (35% vs. 26%, respectively; p = 0.004), but there was no significant difference in the proportion of apoptotic neuronal cells between the groups (57% vs. 43%, respectively; p = 0.165).ConclusionsInduced hypertension significantly attenuated necrotic cell death in the hippocampal CA1 area, but apoptotic cell death was not affected.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Injury - Volume 47, Issue 3, March 2016, Pages 605–608
نویسندگان
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