کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
324420 1433034 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adherence to Pharmacological Treatment for Juvenile Bipolar Disorder
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Adherence to Pharmacological Treatment for Juvenile Bipolar Disorder
چکیده انگلیسی

ABSTRACTObjectiveThe objective of this study was to describe the prevalence and correlates of adherence to divalproex sodium (DVPX) and lithium carbonate (Li) combination treatment during the initial stabilization treatment phase.MethodAdherence to Li/DVPX combination therapy was measured by the presence or absence of minimum serum concentrations of DVPX (50 μg/mL) or Li (0.6 mmol/L). Secondary measures included pill count, patient/parent report, and clinical judgment. Correlates of adherence, including patient characteristics, medication side effects, and family variables, were evaluated.ResultsOne hundred seven patients (70 males and 37 females) were studied. The proportion of serum concentrations in the therapeutic range across the study period was 0.84 for DVPX and 0.66 for Li. Maternal (r = −0.31; p<.01) and paternal (r = −0.44; p < .01) hospitalization for a psychiatric disorder and less adaptive family functioning (r=−0.26; p < .05) related to treatment nonadherence for DVPX. Better treatment adherence to DVPX (r = 0.21; p < .05) and Li (r = 0.23; p < .05) was associated with a greater number of side effects, whereas male sex was associated with worse adherence to both DVPX (r= −0.24; p < .05) and Li (r = −0.22; p < .05) pharmacotherapy. Clinical response to treatment correlated with adherence to DVPX treatment (r = 0.33; p < .01).ConclusionsNonadherence may limit the statistical power of treatment efficacy studies and the effectiveness of pharmacotherapy treatment for juvenile BPD and necessitate strategies to evaluate and enhance levels of treatment adherence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Child & Adolescent Psychiatry - Volume 46, Issue 7, July 2007, Pages 831–839
نویسندگان
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