کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
324478 1432929 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of an Objective Autism Risk Index Using Remote Eye Tracking
ترجمه فارسی عنوان
توسعه یک شاخص ریسک اوتیسم عینی با استفاده از ردیابی چشم از راه دور
کلمات کلیدی
اختلال طیف اوتیسم؛ ردیابی چشم از راه دور؛ اندازه گیری هدف؛ علائم اوتیسم؛ خطر
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
چکیده انگلیسی

ObjectiveAbnormal eye gaze is a hallmark characteristic of autism spectrum disorder (ASD), and numerous studies have identified abnormal attention patterns in ASD. The primary aim of the present study was to create an objective, eye tracking-based autism risk index.MethodIn initial and replication studies, children were recruited after referral for comprehensive multidisciplinary evaluation of ASD and subsequently grouped by clinical consensus diagnosis (ASD n = 25/15, non-ASD n = 20/19 for initial/replication samples). Remote eye tracking was blinded to diagnosis and included multiple stimuli. Dwell times were recorded to each a priori–defined region of interest (ROI) and averaged across ROIs to create an autism risk index. Receiver operating characteristic curve analyses examined classification accuracy. Correlations with clinical measures evaluated whether the autism risk index was associated with autism symptom severity independent of language ability.ResultsIn both samples, the autism risk index had high diagnostic accuracy (area under the curve [AUC] = 0.91 and 0.85, 95% CIs = 0.81–0.98 and 0.71–0.96), was strongly associated with Autism Diagnostic Observation Schedule–Second Edition (ADOS-2) severity scores (r = 0.58 and 0.59, p < .001), and not significantly correlated with language ability (r ≤| –0.28|, p > .095).ConclusionThe autism risk index may be a useful quantitative and objective measure of risk for autism in at-risk settings. Future research in larger samples is needed to cross-validate these findings. If validated and scaled for clinical use, this measure could inform clinical judgment regarding ASD diagnosis and track symptom improvements.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Child & Adolescent Psychiatry - Volume 55, Issue 4, April 2016, Pages 301–309
نویسندگان
, , , , , , , , , , , , , , ,