Protective role of β-caryophyllene, a sesquiterpene lactone on plasma and tissue glycoprotein components in streptozotocin-induced hyperglycemic rats

AimThe aim of present study is to evaluate the effect of β-caryophyllene (BCP), on deranged plasma and tissue glycoprotein components in streptozotocin-induced diabetic rats.MethodsDiabetes was induced in overnight fasted experimental rats by a single intraperitoneal (i.p) injection of STZ (40 mg/kg b.w) dissolved in 0.1 M citrate buffer (pH 4.5). After the induction of diabetes, animals were treated orally with BCP (200 mg/kg b.w) and glibenclamide (600 μg/kg b.w) for 45 days.ResultsA significant increase in glycoprotein components such as hexose, hexosamine, fucose and sialic acid in plasma was noticed in diabetic rats. In hepatic and renal tissues, a significant decrease in sialic acid with increase in other glycoprotein components was observed in diabetic rats when compared with control rats. Oral administration of BCP and glibenclamide significantly reversed the glycoprotein levels in plasma and tissues of diabetic rats to near normal.ConclusionFrom this study, we conclude that BCP ameliorates deranged glycoprotein metabolism in streptozotocin-induced diabetic rats.