Gel-free proteomics reveals neoplastic potential in endometrium of infertile patients with stage IV ovarian endometriosis

It appears highly plausible that endometrial cells in women with stage IV ovarian endometriosis cannot adequately support embryo implantation process due to innate molecular inadequacies. Furthermore, these cells with molecular defects on their reflux into pelvic peritoneal niche may result in endometriotic lesion. Most importantly, pathognomonic characteristics showing marked indication of neoplastic potential in endometrium of infertile patients with stage IV ovarian endometriosis bear a possibility of inducement of oncogenic transformation especially in the high-risk population in the course of endometriosis disease progression.