کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
325621 | 1433018 | 2008 | 11 صفحه PDF | دانلود رایگان |

ObjectiveTo review progress in understanding pediatric obsessive-compulsive disorder (OCD). The focus is on the frontal-striatal-thalamic model of OCD, neurobiological and genetic studies of the disorder, and their influence on recent advances in treatment.MethodComputerized literature searches were conducted with the key words Bobsessive-compulsive disorder” in conjunction with “pediatric,” “genetics,” and “imaging.”ResultsNeuroimaging studies find evidence to support the frontal-striatal-thalamic model. Genetic and neurochemical studies also implicate glutamate in the pathological finding of OCD. This has led to the application of glutamate-modulating agents to treat OCD.ConclusionsStudies of pediatric OCD have led to a refined frontal-striatal-thalamic model of pathogenesis and are having an evidence-based impact on treatment. Despite this progress, fully explanatory models are still needed that would allow for accurate prognosis and the development of targeted and efficacious treatments.
Journal: Journal of the American Academy of Child & Adolescent Psychiatry - Volume 47, Issue 11, November 2008, Pages 1262–1272