کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3259001 1207561 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low early B-cell factor 1 (EBF1) activity in human subcutaneous adipose tissue is linked to a pernicious metabolic profile
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Low early B-cell factor 1 (EBF1) activity in human subcutaneous adipose tissue is linked to a pernicious metabolic profile
چکیده انگلیسی

AimRecently, in both human and murine white adipose tissue (WAT), transcription factor early B-cell factor 1 (EBF1) has been shown to regulate adipocyte differentiation, adipose morphology and triglyceride hydrolysis (lipolysis). This study investigated whether EBF1 expression and biological activity in WAT is related to different metabolic parameters.MethodsIn this cross-sectional study of abdominal subcutaneous WAT, EBF1 protein levels were examined in 18 non-obese subjects, while biological activity was determined in 56 obese and non-obese subjects. Results were assessed by anthropometric measures and blood pressure as well as by plasma lipid levels and insulin sensitivity.ResultsEBF1 protein levels were negatively associated with waist circumference (r = −0.56; P = 0.015), but not with body mass index (BMI) or body fat (P = 0.10–0.29). Biological activity of EBF1 correlated negatively with plasma triglycerides (r = −0.46; P = 0.0005) and plasma insulin (r = −0.39; P = 0.0027), but positively with plasma HDL cholesterol (r = 0.48; P = 0.0002) and insulin sensitivity, as assessed by intravenous insulin tolerance test (r = 0.64; P < 0.0001). These relationships, except for plasma insulin, remained statistically significant after adjusting for BMI and adipose morphology. EBF1 activity was not associated with age, systolic/diastolic blood pressure or total plasma cholesterol (P = 0.17–0.48). In contrast to EBF1 activity, after adjusting for BMI, EBF1 mRNA levels displayed only an association with plasma triglycerides.ConclusionLow EBF1 protein expression and activity in abdominal subcutaneous WAT is a BMI-independent marker for several traits associated with the metabolic syndrome. However, whether EBF1 constitutes a novel treatment target remains to be demonstrated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes & Metabolism - Volume 41, Issue 6, December 2015, Pages 509–512
نویسندگان
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