کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
326043 1644947 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The 22q11.2 Deletion in Children : High Rate of Autistic Disorders and Early Onset of Psychotic Symptoms
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
The 22q11.2 Deletion in Children : High Rate of Autistic Disorders and Early Onset of Psychotic Symptoms
چکیده انگلیسی

ABSTRACTObjectiveTo examine psychopathology and influence of intelligence level on psychiatric symptoms in children with the 22q11.2 deletion syndrome (22q11DS).MethodSixty patients, ages 9 through 18 years, were evaluated. Assessments followed standard protocols, including structured and semistructured interviews of parents, videotaped psychiatric interview, and intelligence assessment of the child. Intelligence level, psychiatric symptoms, and classification provided the main outcome.ResultsHigh rates of autism spectrum disorders (30 of 60, 50.0%) and psychotic symptoms (16 of 60, 26.7%) were found in this sample. In 7 of 60 (11.7%), the psychotic symptoms interfered with behavior and caused considerable distress. In these cases, the diagnosis of a psychotic disorder was applied. The average age of the children with psychotic symptoms at time of assessment was 14.2 years. Although it is likely that the high rate of psychopathology in this sample is to some extent associated with the lower level of cognitive function, a major effect of the degree of cognitive impairment on psychiatric morbidity was not found.ConclusionAutism spectrum disorders and subthreshold autistic symptomatology are common in children with 22q11DS. Furthermore, a high rate of psychosis and psychotic symptoms is found in this childhood sample, suggesting an early onset of psychosis in 22q11DS patients. Autistic and psychotic disorders should be considered to be main elements of the behavioral phenotype of 22q11DS children. J. Am. Acad. Child Adolesc. Psychiatry, 2006;45(9):1104–1113.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Academy of Child & Adolescent Psychiatry - Volume 45, Issue 9, September 2006, Pages 1104–1113
نویسندگان
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