کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3261667 1207704 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Real life adherence of chronic hepatitis B patients to entecavir treatment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Real life adherence of chronic hepatitis B patients to entecavir treatment
چکیده انگلیسی

BackgroundReal-life prospective data on adherence to nucleos(t)ide analogues in chronic hepatitis B patients are scarce.AimsWe investigated adherence to entecavir in relation to virological response.MethodsIn this prospective study, we provided 100 consecutive chronic hepatitis B patients with a medication dispenser that monitored entecavir intake during 16 weeks therapy. Hepatitis B virus (HBV) DNA was measured at baseline and after 16 weeks. Beliefs about medicines were evaluated using a questionnaire.ResultsAdherence over 16 weeks averaged 85 ± 17%, with 70% of patients exhibiting good (i.e. ≥80%) adherence. Patients with poor (i.e. <80%) adherence were significantly younger (p = 0.01), with more often indifferent attitudes towards entecavir (p = 0.03) Viral breakthrough did not occur during the study. Adherence in patients with HBV DNA after 16 weeks >20 IU/mL (n = 18) and ≤20 IU/mL (n = 81) averaged 83% and 91% respectively (p = 0.19). In multivariate analysis, adherence was not a significant predictor of HBV DNA negativity (adjusted OR 1.02; p = 0.34), after adjustment for duration of entecavir treatment (p < 0.001) and HBe-status (p = 0.001).Conclusions70% of chronic hepatitis B patients exhibited good adherence to entecavir, with younger age and an indifferent attitude being risk factors for poor adherence. Poor adherence was not an independent predictor of virological response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 47, Issue 7, July 2015, Pages 577–583
نویسندگان
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