کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3262211 1207726 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An explorative data-analysis to support the choice between hepatic resection and radiofrequency ablation in the treatment of hepatocellular carcinoma
ترجمه فارسی عنوان
یک تجزیه و تحلیل اطلاعات اکتشافی برای حمایت از انتخاب بین رزکسیون کبدی و تخریب رادیوفرکوسی در درمان کارسینوم سلول های بنفش
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundWhether to prefer hepatic resection or radiofrequency ablation as first line therapy for hepatocellular carcinoma is a matter of debate.AimsTo compare outcomes of resection and ablation, in the treatment of early hepatocellular carcinoma, through a decision-making analysis.MethodsData of 388 cirrhotic patients undergoing resection and of 207 undergoing radiofrequency ablation were reviewed. Two distinct regression models were devised and used to perform sensitivity and probabilistic analyses, to overcome biases of covariate distributions.ResultsActuarial survival curves showed no difference between resection and ablation (P = 0.270) despite the fact that ablated patients were older, with worse liver function and smaller, unifocal tumours (P < 0.05), suggesting a complex, non-linear relationship between clinical, tumoral variables and treatments. Sensitivity and probabilistic analyses suggested that the superiority of resection over ablation decreased at higher Model for-End stage Liver Disease scores, and that ablation provided better results for smaller tumours and higher Model for-End stage Liver Disease scores. In patients with 2–3 tumours up to 3 cm, the two treatments produced opposite comparative results in relation to the Model for-End stage Liver Disease score.ConclusionsThe superiority, or the equivalence, of resection and ablation depends on the non-linear relationship existing between treatment, tumour number, size and degree of liver dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 46, Issue 3, March 2014, Pages 257–263
نویسندگان
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