کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3263768 1207769 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Uptake and retention of 65Zn in lithium-treated rat liver: Role of zinc
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Uptake and retention of 65Zn in lithium-treated rat liver: Role of zinc
چکیده انگلیسی

AimTo evaluate the effects of zinc on the biokinetics of 65Zn in rat and its distribution in various organs and in subcellular compartment following lithium therapy.MethodsFemale wistar rats received either lithium treatment at a dose of 1.1 g/kg in diet, zinc alone at a dose of 227 mg/L in drinking water, and combined lithium plus zinc for duration of four months.ResultsAfter four months of lithium treatment, liver enzymes increased significantly (glutamic oxaloacetic transaminase, +66.73%; glutamic pyruvic transaminase, +63.70%; alkaline phosphatase, +40.28%; p ≤ 0.001); zinc supplementation to lithium-treated rats significantly reduced liver enzymes (glutamic oxaloacetic transaminase, −13.11%; glutamic pyruvic transaminase, −21.78%; alkaline phosphatase, −11.77%; p ≤ 0.001). The biological half-lives of 65Zn showed an initial fast component (Tb1) and a slower component (Tb2). A significant increase in Tb2 (38.82%, p ≤ 0.001) in liver was observed following lithium treatment, which significantly decreased following zinc treatment (21.71%, p ≤ 0.001). A significant decrease in the uptake of 65Zn (53.93%, p ≤ 0.01) in liver was observed and in nuclear (p ≤ 0.01), mitochondrial (p ≤ 0.01), and microsomal (52.67%, p ≤ 0.001) fractions. A significant increase in the uptake of 65Zn (82.92%, p ≤ 0.05) in liver microsomal fraction (34.09%, p ≤ 0.001) was observed in lithium-treated rats receiving zinc supplementation.ConclusionThe study suggests that zinc has the potential to regulate the biokinetics of 65Zn and its subcellular distribution in rat liver following lithium therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 42, Issue 6, June 2010, Pages 446–450
نویسندگان
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