کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3263787 | 1207770 | 2010 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis](/preview/png/3263787.png)
BackgroundThe available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality.AimsTo validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward–backward method and then reviewed in focus groups in the framework of a large multicentric study.MethodsA sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36).ResultsThe confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores.ConclusionWe here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients.
Journal: Digestive and Liver Disease - Volume 42, Issue 10, October 2010, Pages 718–723