Keywords: PBC، سیروژن صفراوی اولیه; Primary biliary cirrhosis; Cholangitis; Regulatory T cells; Transcription profile and pathway analysisdnTGFβRII, dominant negative transforming growth factor β receptor II; PBC, primary biliary cirrhosis; Tregs, regulatory T cells; mLN, mesenteric lymph n
مقالات ISI PBC، سیروژن صفراوی اولیه (ترجمه نشده)
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Keywords: PBC، سیروژن صفراوی اولیه; BEC, biliary epthelial cells; CA, cholic acid; CBP, CREB-binding protein; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; FXR, farnesoid X receptor; GR, glucocorticoid receptor; ISG, IFN-stimulated gene; PBC, primary biliary cirrhosis; PKI, PKA inhibi
Keywords: PBC، سیروژن صفراوی اولیه; OLT, orthotopic liver transplantation; ACE, angiotensin converting enzyme; PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis; CTP, Child–Turcotte–Pugh; MELD, Model for End Stage Liver Disease; HCV, hepatitis C virus; DM, diabetes mellitu
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)
Keywords: PBC، سیروژن صفراوی اولیه; SAR, structure–activity-relationship; FXR, farnesoid X receptor; RXR, retinoid X receptor; DMEM, Dulbecco’s modified eagle medium; FCS, fetal calf serum; DMSO, dimethyl sulfoxide; NAFLD, non-alcoholic fatty liver disease; PBC, primary biliary cirrhosis; P
Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; TLR, toll-like receptor; LPS, lipopolysaccharide; SNPs, single nucleotide polymorphisms
Prevalence and clinical significance of rare antinuclear antibody patterns
Keywords: PBC، سیروژن صفراوی اولیه; IIF, indirect immunofluorescence; MND, multiple nuclear dots; PBC, primary biliary cirrhosis; SAID, systemic auto-immune disease; SjS, Sjögren's syndrome; SLE, systemic lupus erythematosusAutoimmunity; Antinuclear antibodies; Autoimmune diseases; Autoanti
Questionnaire based assessment of risk factors for primary biliary cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; AIH, autoimmune hepatitis; AMA, anti-mitochondrial antibodies; FDR, first-degree relative; MCPGE Registry, Mayo Clinic PBC Genetic Epidemiology Registry; PBC, primary biliary cirrhosis; SDR, second-degree relative; SLE, systemic lupus erythematosus; UTI,
Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; CA, cholangitis activity; HA, hepatitis activity; CNSDC, chronic nonsuppurative destructive cholangitis; UDCA, ursodeoxycholic acid; Alp, alkaline phosphatase; γ-GTP, γ-glutamyl transpeptidase; AST, aspartate aminotransfera
Chemoprevention of colorectal cancer with ursodeoxycholic acid: Cons
Keywords: PBC، سیروژن صفراوی اولیه; CRC, Colorectal cancer; PBC, Primary biliary cirrhosis; PSC, Primary sclerosing cholangitis; UC, Ulcerative colitis; UDCA, Ursodeoxycholic acid
Performance of anti-deamidated gliadin peptides antibodies in celiac disease diagnosis
Keywords: PBC، سیروژن صفراوی اولیه; a-DGP, Anti-deamidated gliadin peptides antibodies; CD, Celiac disease; AEA, Anti-endomysium antibodies; AtTG, Anti-tissue transglutaminase antibodies; BD, Blood donors; HC, Healthy children; PBC, Primary biliary cirrhosis; GFD, Gluten-free diet; PVA, Par
Geoepidemiology, gender and autoimmune disease
Keywords: PBC، سیروژن صفراوی اولیه; ADs, autoimmune diseases; SLE, systemic lupus erythematosus; PBC, primary biliary cirrhosis; pSS, primary Sjögren's Syndrome; GWAS, genome wide association studies; HLA, human leukocyte antigens; RA, rheumatoid arthritis; MS, multiple sclerosis; T1D, type
Primary biliary cirrhosis and bile acids
Keywords: PBC، سیروژن صفراوی اولیه; FXR, Farnesoid X receptor; PBC, Primary biliary cirrhosis; PPARα, peroxisome proliferator-activated receptor alpha; PXR, Pregnane X receptor; UDCA, ursodeoxycholic acid
FXR and PXR: Potential therapeutic targets in cholestasis
Keywords: PBC، سیروژن صفراوی اولیه; BDL, bile duct ligation; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; FXR, Farnesoid X Receptor; LCA, lithocholic acid; LXR, liver X receptor; NR, nuclear receptor; PBC, primary biliary cirrhosis; PCN, pregnenolone 16α-carbonitrile
Alkaline phosphatase normalization is associated with better prognosis in primary sclerosing cholangitis
Keywords: PBC، سیروژن صفراوی اولیه; ALP, alkaline phosphatase; AST, aspartate aminotransferase; PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis; UDCA, ursodeoxycholic acidAlkaline phosphatase; Primary sclerosing cholangitis; Ursodeoxycholic acid
Long-term ursodeoxycholate improves circulating redox changes in primary biliary cirrhotic patients
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; PSH, protein sulfhydryls; NO, nitric oxide; iNOS, inducible nitric oxide synthase; eNOS, endothelial nitric oxide synthase; BDL, bile duct ligation; PSSG, protein-glutathione mixed disulfides; UDCA, ursodeoxycholateGlutathi
The long-term effect of ursodeoxycholic acid on laboratory liver parameters in biochemically non-advanced primary biliary cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; UDCA, Ursodeoxycholic Acid; PBC, Primary biliary cirrhosis; ALP, Alkaline phosphatase; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; AMA, Antimitochondrial antibodies
LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats
Keywords: PBC، سیروژن صفراوی اولیه; Mrp2, multidrug resistance-associated protein 2; Bsep, bile-salt export pump; PBC, primary biliary cirrhosis; HCV, hepatitis C virus; BDL, bile duct ligation; nPKC, novel protein kinase C; LPS, lipopolysaccharide; ERM, ezrin–radixin–moesin; F-actin, actin
Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status
Keywords: PBC، سیروژن صفراوی اولیه; Mrp2, multidrug resistance-associated protein 2; BSEP, bile-salt export pump; GSH, glutathione; PBC, primary biliary cirrhosis; t-BHP, tert-butylhydroperoxide; LPS, lipopolysaccharide; PKA, protein kinase A; ERM, ezrin/radixin/moesin; cPKC, conventional P
B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis
Keywords: PBC، سیروژن صفراوی اولیه; AMA, anti-mitochondrial autoantibodies; CBD, common bile duct; Idd, insulin dependent diabetes; NK, natural killer; NOD, nonobese diabetes; PBC, primary biliary cirrhosis; PDC, pyruvate dehydrogenase complex; TGF-β, transforming growth factor-βB cells; Au
Bone Disease in Patients With Primary Sclerosing Cholangitis
Keywords: PBC، سیروژن صفراوی اولیه; Cholestatic Liver Disease; Autoimmune Liver Disease; Osteoporosis; Inflammatory Bowel DiseaseBMD, bone mineral density; BMI, body mass index; CI, confidence interval; OR, odds ratio; PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis
Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription
Keywords: PBC، سیروژن صفراوی اولیه; STAT, signal transducer and activator of transcription; GRIM-19, genes associated with retinoid-interferon-induced mortality-19; ETC, electron transport chain; PDC, pyruvate dehydrogenase complex; PBC, primary biliary cirrhosis; IL-3, interleukin-3; SOCS,
A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; HRQoL, health related quality of life; CFA, confirmatory factor analysis; CFI, comparative fit index; GFI, goodness of fit index; AGFI, adjusted goodness of fit index; RMSEA, root mean square error of approximation; CAIC, c
Viral triggers for autoimmunity: Is the ‘glass of molecular mimicry’ half full or half empty?
Keywords: PBC، سیروژن صفراوی اولیه; Cytochrome P450; Virus infection; Tolerance; Liver disease; InflammationGBS, Guillain Barré syndrome; PDC, pyruvate dehydrogenase complex; PBC, primary biliary cirrhosis; 1-OA, 2-octoynoic acid; AIH, autoimmune hepatitis; T1D, type 1 diabetes; LCMV, lymph
Update on primary biliary cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; AMA, anti-mitochondrial antibodies; IgM, immunoglobulin M; ANA, anti-nuclear antibody; PDC-E2, E2 subunit of pyruvate dehydrogenase; HLA, human leukocyte antigen; XCI, X-chromosome inactivation; dnTGFβRII, dominant negative
Hepatic VASP upregulation in rats with secondary biliary cirrhosis by expression in the peribiliary vascular plexus
Keywords: PBC، سیروژن صفراوی اولیه; BDL, bile duct ligation, bile duct-ligated; CCl4, carbon tetrachloride; cDNA, copy desoxyribonucleic acid; Ct, number of cycles; mRNA, messenger ribonucleic acid; PBC, primary biliary cirrhosis; PBP, peribiliary vascular plexus; PSC, primary sclerosing ch
Primary biliary cirrhosis is associated with altered hepatic microRNA expression
Keywords: PBC، سیروژن صفراوی اولیه; Autoimmune liver diseases; MicroRNA; Primary biliary cirrhosismiRNAs, microRNAs; 3′ UTR, 3′ untranslated region; PBC, primary biliary cirrhosis; AMA, anti-mitochondrial antibodies; PDC-E2, E2 subunit of the pyruvate dehydrogenase enzyme complex; Limma, li
Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium
Keywords: PBC، سیروژن صفراوی اولیه; CDCA, chenodeoxycholic acid; ERK, extracellular regulated kinase; FXR, farnesoid X receptor; hBD-2, human β 2 defensins; PBC, primary biliary cirrhosis; PCR, polymerase chain reaction; VDR, vitamin D nuclear receptor; VDRE, VDR response element
A possible role of histone-like DNA-binding protein of Streptococcus intermedius in the pathogenesis of bile duct damage in primary biliary cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; BEC, biliary epithelial cells; CNSDC, chronic non-suppurative destructive cholangitis; CH-C, chronic hepatitis due to hepatitis C virus; HLP, histone-like protein; LTA, lipoteichoic acid; AMA, anti-mitochondrial antibody; P
Primary Biliary Cirrhosis Is Associated With a Genetic Variant in the 3′ Flanking Region of the CTLA4 Gene
Keywords: PBC، سیروژن صفراوی اولیه; AMA, anti-mitochondrial antibody; CTLA4, cytotoxic T-lymphocyte antigen 4; LD, linkage disequilibrium; OLT, orthotopic liver transplantation; PBC, primary biliary cirrhosis; SNP, single nucleotide polymorphism; UTR, untranslated region
Portal Hypertension and Primary Biliary Cirrhosis: Effect of Long-Term Ursodeoxycholic Acid Treatment
Keywords: PBC، سیروژن صفراوی اولیه; AP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; PBC, primary biliary cirrhosis; PHG, portohepatic gradient
Human Parathyroid Hormone 1–34 Prevents Bone Loss in Experimental Biliary Cirrhosis in Rats
Keywords: PBC، سیروژن صفراوی اولیه; BDL, bile duct-ligated; DPD, deoxypyridinoline cross-links; hPTH, human parathyroid hormone; μCT, microcomputerized tomography; PBC, primary biliary cirrhosis; SO, sham operation
Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial–mesenchymal transition (EMT) in cholangiocytes
Keywords: PBC، سیروژن صفراوی اولیه; BEC, biliary epithelial cell; C-SFM, complete serum-free medium; EDC, epidermal differentiation complex; EMT, epithelial–mesenchymal transition; HMGB1, high mobility group box 1; PBC, primary biliary cirrhosis; SPRR protein, small proline-rich protein; RO
Prevalence and Predictors of Esophageal Varices in Patients With Primary Biliary Cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; AMA, antimitochondrial antibody; EGD, esophagogastroduodenoscopy; PBC, primary biliary cirrhosis; UDCA, ursodeoxycholic acid
Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; TLR, Toll-like receptor; LPS, lipopolysaccharide; PGN, peptidoglycan; PBMCs, peripheral blood mononuclear cells; CBA, Cytometric Bead Array; IL, interleukin; FITC, fluorescein isothiocyanate; PE, phycoerythrinInnate immunit
Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection
Keywords: PBC، سیروژن صفراوی اولیه; HCV, hepatitis C virus; PBC, primary biliary cirrhosis; 3P3, forkhead box protein FOXP3; PBMC, peripheral blood mononuclear cell; CTLA, cytotoxic T lymphocyte antigen; IL, interleukin; TGF, transforming growth factor; IFN, interferonRegulatory T cell; FOX
Hepatitis C is associated with perturbation of intrahepatic myeloid and plasmacytoid dendritic cell function
Keywords: PBC، سیروژن صفراوی اولیه; HCV, hepatitis C virus; PBC, primary biliary cirrhosis; ALD, alcoholic liver diseases; CC; cryptogenic cirrhosis; mDC, myeloid dendritic cell; pDC, plasmacytoid dendritic cellHuman; Dendritic cells; HCV
Improved anti-IgG and HSA affinity ligands: Clinical application of VHH antibody technology
Keywords: PBC، سیروژن صفراوی اولیه; DCM, dilated cardiomyopathy; DTT, dithiothreitol; GMP, good manufacturing process; GP, Goodpasture; GRAS, generally recognized as safe; HSA, human serum albumin; IgG, immunoglobulin G; NHS, N-hydroxysulfosuccinimide; PBC, primary biliary cirrhosis; SLE, s
Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis
Keywords: PBC، سیروژن صفراوی اولیه; Autoepitope; Microarray platform; Primary biliary cirrhosis; XenobioticsAMA, anti-mitochondrial antibody; QSAR, quantitative structure–activity relationship; PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis; PDC, pyruvate dehydrogenase
CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2
Keywords: PBC، سیروژن صفراوی اولیه; PBC, primary biliary cirrhosis; TNFR, tumour necrosis factor receptor; FasL, Fas ligand; Mab, monoclonal antibody; TNF-α, tumour necrosis factor-alpha; STAT3, signal transducer and activator of transcription 3; pSTAT3, phospho-STAT3; JAK1/2/3, janus tyros