کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3338436 1407731 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A Single Center Experience
ترجمه فارسی عنوان
نتایج بلندمدت پیوند کبدی برای سارکوئیدوز کبدی: یک تجربه تک مرکز
کلمات کلیدی
OLT، پیوند کبد ارتوتوپیک؛ ACE، آنزیم تبدیل کننده آنژیوتانسین. PBC، سیروژن اولیه صفراوی؛ PSC، کلانژیت اسکلروزیس اولیه؛ CTP، Child-Turcotte-Pugh؛ MELD، مدل بیماری کبد مرحله پایانی؛ HCV، ویروس هپاتیت C؛ DM، دیابت نوع یک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کبدشناسی
چکیده انگلیسی

AimHepatic sarcoidosis is a rare indication for orthotopic liver transplantation (OLT). Hence, studies evaluating these patients are scarce. We present a single center experience with OLT for hepatic sarcoidosis in a case–control study.MethodsA retrospective chart review was performed on 970 patients with OLT at our center, and 13 patients (1.3%) were identified who underwent 14 OLTs for hepatic sarcoidosis. For each case, two controls matched for etiology of liver disease, recipient age (±5 years), and duration since transplant (within 5 years) were selected.ResultsFor the 13 patients transplanted for sarcoidosis, the median age was 46 years. The majority were women (62%) and African-American (85%). Cholestatic liver disease was the primary manifestation. Portal hypertensive complications were present in 11 patients (84%). The median MELD score at transplantation was 19. Extra-hepatic manifestations were present in ten patients (77%). All patients received whole deceased 14 donor allografts. Six patients remain alive with a median post-OLT follow-up of 8.4 years. The 1-, 3-, 5-, and 10-year patient survival rates were 84.6%, 76.9%, 61.1%, and 51.3%, respectively for the sarcoidosis group and 82.1%, 78.6%, 78.6%, and 61.9%, respectively for the matched PSC/PBC group (P = 0.739). Re-graft free survival for sarcoidosis patients was 84.6%, 76.9%, 61.5%, and 51.3% for 1-, 3-, 5-, and 10-years and for the matched control group re-graft free survival was 78.6% at 1-, 3-, 5-years, and 64.8% at 10-years (P = 0.661). Recurrence of hepatic sarcoidosis was found in 4 patients at 11 days, 112 days, 222 days, and 6.6 years.ConclusionsOur study depicts the long-term benefit of liver transplantation in patients with end stage liver disease secondary to sarcoidosis. It shows statistically comparable graft and patient survival for such patients when compared to other cholestatic diseases. Disease recurrence, although possible, has not been shown to cause allograft dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical and Experimental Hepatology - Volume 6, Issue 2, June 2016, Pages 94–99
نویسندگان
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