کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3265053 | 1207803 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Peginterferon plus Ribavirin for chronic hepatitis C in opiate addicts on methadone/buprenorphine maintenance therapy Peginterferon plus Ribavirin for chronic hepatitis C in opiate addicts on methadone/buprenorphine maintenance therapy](/preview/png/3265053.png)
BackgroundIn developed countries hepatitis C is prevalently transmitted by intravenous drug users (IDUs). The problems associated with management of HCV hepatitis in these patients have, in the past, discouraged treatment.AimTo evaluate efficacy, safety and tolerability of a standard Peginterferon (Peg-IFN) α-2b or α-2a plus Ribavirin treatment in IDUs who were receiving methadone or buprenorphine.MethodsA multi-centre prospective observational study performed from September 2003 to September 2006 in Central Italy (Umbria and Marches regions). A shared care model of HCV management was used which integrated a multidimensional, multidisciplinary approach.ResultsSixty-five subjects were evaluated and 52 satisfied inclusion criteria. Forty-five completed treatment (25 with Peg-IFN α-2b, 20 with Peg-IFN α-2a), a total of 37 showed a biochemical/virological response at the end of treatment (ITT 71.1%), 26 had a sustained virological response (ITT 50%; 38.4% of cases genotype 1-4, 61.6% genotype 3-2).ConclusionsThe results indicate that patients on maintenance treatment with methadone/buprenorphine can be treated for HCV. The success rate was fairly good; tolerability and side effects were similar to those reported in non-IDU patients. Close cooperation with specialists in drug addiction and psychiatrists is however essential for success.
Journal: Digestive and Liver Disease - Volume 41, Issue 4, April 2009, Pages 303–307