کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
326538 | 542458 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traits Dopamine response to psychosocial stress in humans and its relationship to individual differences in personality traits](/preview/png/326538.png)
BackgroundPrevious studies have reported inter-individual variability in the dopamine (DA) response to stress. This variability might be related to individual differences in the vulnerability to experience the negative effect of stress.ObjectiveTo investigate whether personality traits as measured by the Revised NEO Personality Inventory explain variability in DA response to a psychosocial stress task.MethodsEleven healthy adults, mean age of 26 ± 3.87 underwent two Positron Emission Tomography (PET) scans using the dopamine D2/3 agonist, [11C]-(+)-PHNO under a control and stress condition. The Simplified Reference Tissue Model (SRTM) was used to obtain [11C]-(+)-PHNO Binding Potential (BPND). Stress-induced DA response was indexed as a percent change in [11C]-(+)-PHNO BPND between control and stress conditions. The regions of interest were defined into D2-rich regions, which included the Associative and Sensorimotor Striatum (AST and SMST); D2/3 mixed regions, which included the Limbic Striatum (LST) and Globus Pallidus (GP); and D3-rich region, which included the Substantia Nigra (SN).ResultsSeveral personality traits within the Neuroticism and Openness to Experience domain were significantly correlated with blunted DA response to stress. Specifically, the Angry-Hostility, Vulnerability, and Depression trait were associated with blunted DA stress response in the AST (r = −0.645, p = 0.032), LST (r = −0.677, p = 0.022) and GP (r = −0.736, p = 0.010), respectively. The Openness to Values was correlated with a decreased DA release in the SN (r = −0.706, p = 0.015).ConclusionVariability in DA stress response might be related to individual differences in personality.
Journal: Journal of Psychiatric Research - Volume 46, Issue 7, July 2012, Pages 890–897