کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3266009 1207830 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
L-Carnitine in the treatment of fatigue in adult celiac disease patients: A pilot study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
L-Carnitine in the treatment of fatigue in adult celiac disease patients: A pilot study
چکیده انگلیسی

BackgroundFatigue is common in celiac disease. L-Carnitine blood levels are low in untreated celiac disease. L-Carnitine therapy was shown to improve muscular fatigue in several diseases.AimTo evaluate the effect of L-carnitine treatment in fatigue in adult celiac patients.MethodsRandomised double-blind versus placebo parallel study. Thirty celiac disease patients received 2 g daily, 180 days (L-carnitine group) and 30 were assigned to the placebo group (P group). The patients underwent clinical investigation and questionnaires (Scott-Huskisson Visual Analogue Scale for Asthenia, Verbal Scale for Asthenia, Zung Depression Scale, SF-36 Health Status Survey, EuroQoL). OCTN2 levels, the specific carnitine transporter, were detected in intestinal tissue.ResultsFatigue measured by Scott-Huskisson Visual Analogue Scale for Asthenia was significantly reduced in the L-carnitine group compared with the placebo group (p = 0.0021). OCTN2 was decreased in celiac patients when compared to normal subjects (−134.67% in jejunum), and increased after diet in both celiac disease treatments. The other scales used did not show any significant difference between the two celiac disease treatment groups.ConclusionL-Carnitine therapy is safe and effective in ameliorating fatigue in celiac disease. Since L-carnitine is involved in muscle energy production its decreased absorption due to OCTN2 reduction might explain muscular symptoms in celiac disease patients. The diet-induced OCTN2 increase, improving carnitine absorption, might explain the L-carnitine treatment efficacy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 39, Issue 10, October 2007, Pages 922–928
نویسندگان
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