کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
326940 542659 2016 8 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of sICAM-1 and sVCAM-1 as biomarkers in early and late stages of schizophrenia
ترجمه فارسی عنوان
نقش sICAM-1 و sVCAM-1 به عنوان نشانگرهای زیستی در مراحل اول و آخر اسکیزوفرنی
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تولید محتوا
با 10 درصد تخفیف ویژه دانشیاری
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• sICAM-1 levels in the early stage of SZ were comparable to healthy controls.
• sICAM-1 levels were elevated in the late stage of SZ compared to healthy controls.
• sVCAM-1 levels were decreased in both stages of SZ compared to healthy controls.
• sICAM-1 was related to the severity and type of symptoms in the early stage of SZ.
• Lower sICAM-1 was related to favorable treatment application in both stages of SZ.

Schizophrenia (SZ) is a neuroprogressive disorder presenting with biochemical, functional, and structural changes, which differ from early to late stages of the illness. We explored the differences in serum levels of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) between early and late stages of SZ, in regard to clinical characteristics and treatment application.Serum levels of sICAM-1 and sVCAM-1 were measured in 80 patients with SZ (40 early stage; 40 late stage), and compared with 80 healthy controls, matched by age, gender, body mass index, and smoking habits with each SZ group. Serum levels of sICAM-1 and sVCAM-1 were measured using ELISA. The severity of psychopathology was assessed using the Clinical Global Impression Scale and five-factor Positive and Negative Symptoms in Schizophrenia Scale.After adjustment for confounders, we noticed normal levels of sICAM-1 in the early stage, and elevated levels of sICAM-1 in the late stage of SZ. sVCAM-1 levels were decreased in both stages of SZ. Higher sICAM-1 levels have been related to more pronounced cognitive deficit and excitement symptoms in the early stage of SZ and to favorable characteristics of treatment application in both stages.SZ is associated with changes in the levels of adhesion molecules that vary from early to late stages of the illness. This implies that the concept of biochemical staging is applicable in SZ, at least for markers of cellular adhesion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 73, February 2016, Pages 45–52
نویسندگان
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