Génétique du diabète de type 2 et de l'obésité : où en sommes-nous ? Que pouvons-nous en attendre ?

Type 2 diabetes (T2D) and obesity are multifactorial disorders with a strong genetic basis. The sequencing of the human genome and the Hapmap project of frequent DNA variation have made possible dramatic progress in the understanding of the molecular determinants of both afflictions. Indeed, Genome Wide Association studies (GWAS) have identified dozens of loci contributing to the risk of these conditions. Next Generation Sequencing (NGS) will certainly identify rare functional genetic variants causing extreme diabetes and obesity phenotypes and/or strongly increasing disease risk opening new avenues in metabolic personalized medicine.