Existe-t-il une génétique des complications des diabètes ?

Diabetes constitutes a major public health problem. Epidemiological evidence suggests that genetic factors can affect the course of diabetes complications. Several approaches have been used to identify genes contributing to complications, ranging from relatively simple analysis of specific candidate genes in small case-control comparisons to systematic evaluations of the human genome using genome scans and linkage analysis in large collections of individuals and families. The search for a genetic basis of diabetes complications is an important avenue to examine their pathophysiologies. However, it is premature to apply the current findings in this domain to diabetes patient care.