کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3275139 1208496 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
La 11β-hydroxystéroïde déshydrogénase de type 1 - 2e partie Inhibition sélective pour traiter les anomalies métaboliques associées à l'obésité
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
La 11β-hydroxystéroïde déshydrogénase de type 1 - 2e partie Inhibition sélective pour traiter les anomalies métaboliques associées à l'obésité
چکیده انگلیسی
11β-hydroxysteroid dehydrogenase type 1 (11HSD1), which converts cortisone (inactive) into cortisol (active) in target tissues, is overexpressed in presence of abdominal obesity and may play a role in associated metabolic abnormalities. Non selective inhibitors of 11HSD1 have already been tested in humans, but without great success. However, ongoing development of more powerful and selective inhibitors opens new perspectives. Preliminary results appear promising, with reduced insulin resistance, improved glucose tolerance and less marked disturbances related to metabolic syndrome. If these results are confirmed, selective 11HSD1 inhibitors may represent a new class of oral antidiabetic agents in a near future. The aim of the present article is to present the rationale and human data supporting the development of selective 11HSD1 for therapeutic use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Médecine des Maladies Métaboliques - Volume 3, Issue 6, December 2009, Pages 595-600
نویسندگان
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