کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
327619 542942 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy
چکیده انگلیسی

ObjectiveApproximately 30% of patients with depression fail to respond to a selective serotonin reuptake inhibitor (SSRI). Few studies have attempted to define these patients from a biological perspective. Studies suggest that overall patients with depression show increased production of proinflammatory cytokines. We examined pro- and anti-inflammatory cytokine levels in patients who were SSRI resistant.MethodsPlasma concentrations of IL-6, IL-8, IL-10, TNF-α and sIL-6R were measured with enzyme linked immunosorbent assays (ELISA) in DSM-1V major depressives who were SSRI resistant, in formerly SSRI resistant patients currently euthymic and in healthy controls.ResultsPatients with SSRI-resistant depression had significantly higher production of the pro-inflammatory cytokines IL-6 (p = 0.01) and TNF-α (p = 0.004) compared to normal controls. Euthymic patients who were formerly SSRI resistant had proinflammatory cytokine levels which were similar to the healthy subject group. Anti-inflammatory cytokine levels did not differ across the 3 groups.ConclusionSuppression of proinflammatory cytokines does not occur in depressed patients who fail to respond to SSRIs and is necessary for clinical recovery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 41, Issues 3–4, April–June 2007, Pages 326–331
نویسندگان
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