کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3276617 1208582 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nutrient intake in Italian obese patients: Relationships with insulin resistance and markers of non-alcoholic fatty liver disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Nutrient intake in Italian obese patients: Relationships with insulin resistance and markers of non-alcoholic fatty liver disease
چکیده انگلیسی

ObjectiveWe investigated the prevalence of insulin resistance, elevated liver enzymes, and Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS) in obese and severely obese patients. Relations between inadequate nutrient intakes and the markers of metabolic and hepatic disorders were evaluated.MethodsFrom January to September 2009, 63 consecutive obese patients (21 men and 42 women, 19–68 y old) were admitted to the study. According to the World Health Organization obesity classification, patients were categorized into three subgroups (classes I, II, and III). NFS scores lower than −1.455 were defined as NFS−; higher scores were positive (NFS+). Insulin resistance (IR) was assessed by the homeostasis model assessment. Nutrient intakes and their potential role as risk factors for IR and liver damage were determined.ResultsBody mass index ranged from 30.9 to 73.7 kg/m2 and most patients (54%) were in class III (body mass index ≥40 kg/m2). Homeostasis model assessment of IR (>2.5) was recorded in 63.5%. The prevalence of NFS+ was significantly higher in class III than in classes II and I. Excessive nutrient and energy intake prevalence showed significant differences for protein, fat, and carbohydrate among the obesity classes. Animal protein (odds ratio 3.43, 95% confidence interval 1.15–10.20) and carbohydrate (odds ratio 3.83, 95% confidence interval 1.33–10.94) intakes were the risk factors for IR and NFS+.ConclusionNon-normal alanine aminotransferase and γ-glutamyltranspeptidase values were observed in less than one-third of patients, whereas NFS+ and IR were significantly prevalent, suggesting a close relation between the progression of liver fibrosis and metabolic derangement. An excessive intake of animal protein is associated with an increased risk of IR. Carbohydrate intake, albeit at the highest limit of the recommended dietary allowance range, is associated with an increased risk of liver fibrosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 27, Issue 6, June 2011, Pages 672–676
نویسندگان
, , , , , , ,