کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3276972 | 1208598 | 2009 | 11 صفحه PDF | دانلود رایگان |
ObjectivePostprandial hyperglycemia is thought to cause inflammation in many tissues. In this study, we examined whether the gene expression of inflammatory cytokines/cytokine-like factors in peripheral leukocytes are altered by feeding streptozotocin-treated rats a diet containing an α-glucosidase inhibitor, miglitol.MethodsUpregulated gene expression in peripheral leukocytes of streptozotocin-induced hyperglycemic rats was determined by microarray analysis. We examined whether gene expression was altered by supplementing the diet with miglitol.ResultsMicroarray analysis revealed that gene expression of interleukin-1β and putative inflammatory cytokines, S100a4/6/8/9, was induced by streptozotocin treatment. Dietary supplementation with miglitol to the streptozotocin-induced hyperglycemic rats for 20 d not only increased plasma concentrations of a marker for glucose fluctuations, 1,5-anhydroglucitol, the concentration of which is decreased by sustained or postprandial elevated blood glucose levels, but also suppressed the induction of interleukin-1β and S100a4/6/8/9 genes by hyperglycemia.ConclusionThese results suggest that miglitol inhibits the gene expression of inflammatory cytokines/cytokine-like factors in peripheral leukocytes by suppressing glucose fluctuations.
Journal: Nutrition - Volume 25, Issue 6, June 2009, Pages 657–667