کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3277338 1208612 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Grapefruit pulp increases antioxidant status and improves bone quality in orchidectomized rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Grapefruit pulp increases antioxidant status and improves bone quality in orchidectomized rats
چکیده انگلیسی

ObjectiveOrchidectomy causes oxidative stress and increases the incidence of osteoporosis. The objective of this research was to evaluate whether eating grapefruit pulp (GP) modifies antioxidant status and reduces osteoporosis in orchidectomized rats.MethodsFifty-six 90-d-old male Sprague-Dawley rats were randomized into two groups: sham-control group (n = 14) and orchidectomized (ORX) group (n = 42). The orchidectomized group was equally divided among the following three treatments: orchidectomy, orchidectomy + 5.0% GP, and orchidectomy + 10% GP. At the termination of the study (day 60), all rats were euthanized and the plasma was collected for antioxidant status and indices of bone turnover. Bone quality and mineral contents in the bone, urine, and feces were evaluated.ResultsOrchidectomy lowered (P < 0.05) antioxidant status, bone quality, bone mineral contents and elevated (P < 0.05) indices of bone turnover, urinary deoxypyridinoline, and fecal calcium excretion. In contrast to the ORX group, independent of dosage, antioxidant status, bone density, and delayed time-induced femoral fracture were higher (P < 0.05) in the GP groups, whereas fecal calcium excretion and urinary deoxypyridinoline excretion were lowered (P < 0.05). GP dose-dependently slowed down bone turnover (P < 0.05), elevated bone calcium and magnesium contents (P < 0.05), tended to lower urinary excretion of magnesium, and numerically improved bone strength.ConclusionThe beneficial effects of eating red grapefruit on bone quality of ORX rats is due to bone mineral deposition and slowed-down bone turnover.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 24, Issue 10, October 2008, Pages 1039–1044
نویسندگان
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