کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
3277388 1589683 2008 6 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Gastric colonization predisposes to septic morbidity in surgical patients: A prospective study
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موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Gastric colonization predisposes to septic morbidity in surgical patients: A prospective study
چکیده انگلیسی

ObjectiveSeveral previous studies have suggested that pathological colonization of the proximal gastrointestinal (GI) tract may be associated with septic morbidity. However, the prevalence of this in surgical patients is unknown and there is little information on factors that might predispose to this phenomenon. The aim of this study was to assess the preoperative variables that are associated with pathological colonization of the proximal GI tract in surgical patients.MethodsNasogastric aspirates were obtained from 502 surgical patients to identify abnormal colonization. Several preoperative variables were tested to identify association with pathological colonization of the proximal GI tract. Postoperative septic morbidity was recorded prospectively in all patients.ResultsEnterobacteriaceae were identified in 78 of 502 patients (15.5%), 124 of 502 (24.7%) had multiple organisms, and 157 of 502 (31.3%) had Candida in the nasogastric aspirates. Age >70 y and emergency surgery were associated with presence of Enterobacteriaceae. Age >70 y was also associated with the presence of multiple organisms (with or without Enterobacteriaceae). Colonization with Enterobacteriaceae or presence of multiple organisms in the proximal GI tract was associated with postoperative septic morbidity. Preoperative total parenteral nutrition was associated with Candida colonization in the upper GI tract, but not with sepsis.ConclusionPathological colonization of the proximal GI tract with Enterobacteriaceae or multiple organisms is associated with increased incidence of postoperative sepsis. Age >70 y and emergency surgery were the two preoperative variables associated with pathological colonization in surgical patients. Preoperative total parenteral nutrition is associated with fungal colonization but this is not associated with septic morbidity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 24, Issues 7–8, July–August 2008, Pages 632–637
نویسندگان
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