کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3277452 1208618 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation
چکیده انگلیسی

ObjectiveThe aim of the present study was to determine the effects of peroral encapsulated Bifidobacteria on intestinal microflora, bacterial translocation (BT), plasma endotoxin, and ileal villi injury in a rat model of hemorrhagic shock.MethodsSprague-Dawley rats were fed daily with three different diet supplements: phosphate buffered saline, Bifidobacteria (109 colon-forming units/day), or microencapsulated Bifidobacteria (109 colony-forming units/day). After 7 d of treatment, rats were anesthetized for hemorrhagic or sham shock. Then a laparotomy was performed to determine microbiological analysis of cecal content, BT to mesenteric lymph nodes, plasma endotoxin, and terminal ileal villous damage.ResultsIn the hemorrhagic-shock model, rats pretreated with Bifidobacteria showed decreases in total aerobes in cecum, magnitude of total aerobes to BT, levels of plasma endotoxin, and percentage of ileal villous damage when compared with rats treated with phosphate buffered saline. Encapsulated Bifidobacteria induced greater decreases than intact Bifidobacteria in this model, except for no difference in percentage of ileal villous damage between the two groups. In addition, the incidence of BT was decreased in hemorrhagic rats pretreated with Bifidobacteria compared with control. However, the magnitude of total anaerobes and Bifidobacteria BT were similar among hemorrhagic-shocked rats receiving three different supplements.ConclusionBifidobacteria can be useful in preventing BT in hemorrhagic-shocked rats, and encapsulated Bifidobacteria can augment this effect further. Peroral administration of Bifidobacteria may be a favorable strategy to prevent sepsis and multiple organ dysfunction syndrome in hemorrhagic shock.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 23, Issue 10, October 2007, Pages 754–761
نویسندگان
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