کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3277593 1208625 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interactions of high amylose starch and deoxycholic acid on gut functions in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Interactions of high amylose starch and deoxycholic acid on gut functions in rats
چکیده انگلیسی

ObjectiveThis study evaluated whether high amylose cornstarch (HAS) could prevent adverse physiologic effects induced by deoxycholic acid (DCA) in the gut of rats.MethodsThirty-two male Sprague-Dawley rats were provided with a low amylose cornstarch (LAS) diet or a 50/50 mixture of LAS and HAS diets for 4 wk; each of these diets was supplemented with 0 or 2 g of DCA per kilogram of diet. Therefore, there were four groups.ResultsCecal content pH was lower in rats fed the HAS diets compared with rats fed the LAS diets (P < 0.05). Bifidobacteria number in cecal contents, cecal pools of acetate, butyrate, and total short-chain fatty acids were highest in rats fed the HAS diet; moreover, the HAS/DCA diet resulted in increased Bifidobacteria growth and short-chain fatty acid production numerically compared with the LAS/DCA diets (P = 0.06). Production of prostaglandin-E2 in colonic mucosa was highest in rats fed the LAS/DCA diet, and the intake of HAS significantly decreased prostaglandin-E2 levels (P < 0.05).ConclusionsIn this study, DCA may have inhibited fermentation in the large intestine and increased prostaglandin-E2 production, and concurrent administration of HAS and DCA may have decreased the adverse effects on the gut induced by DCA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 22, Issue 2, February 2006, Pages 152–159
نویسندگان
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