کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
327880 543009 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The emerging field of retinal electrophysiological measurements in psychiatric research: A review of the findings and the perspectives in major depressive disorder
ترجمه فارسی عنوان
زمینه در حال ظهور اندازه گیری های الکتروفیزیولوژیک شبکیه در تحقیقات روانپزشکی: مرور یافته ها و دیدگاه ها در اختلال افسردگی عمده
کلمات کلیدی
اختلال افسردگی عمده، الکتروترینوگرام، الکتروکولوگرافی، پاتوفیزیولوژی، نشانگر بیولوژیک، انتقال دهنده ی مونوآمین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Retinal electrophysiological abnormalities were observed in depression.
• Flash electroretinogram may serve to monitor drug response in depressed patients.
• Pattern electroretinogram may be used to differentiate depressed patients and controls.
• Retinal electrophysiological measurements might reflect the pathophysiology of depression.

Major depressive disorder (MDD) is a severe mental illness leading to long-term disabilities. One of the current challenges in psychiatric research is to develop new approaches to investigate the pathophysiology of MDD and monitor drug response in order to provide better therapeutic strategies to the patients. Since the retina is considered as part of the central nervous system, it was suggested that it constitutes an appropriate site to investigate mental illnesses. In the past years, several teams assessed the retinal function of patients with mood disorders and many relevant abnormalities have been reported. Investigation of the retinal electrophysiological abnormalities in MDD remains a young emerging field, but we believe that the current findings are very promising and we argue that objective retinal electrophysiological measurements may eventually become relevant tools to investigate the pathophysiology of MDD. Here, we review the retinal abnormalities detected with objective electrophysiological measurements such as the flash electroretinogram (fERG), the pattern electroretinogram (PERG) and the electrooculogram (EOG) in patients with MDD. We discuss how these changes might reflect the pathophysiology of MDD in both clinical and scientific points of view, according especially to the monoamine neurotransmission deficiency hypothesis. We also discuss the technical details that must be taken into consideration for a potential use of the objective retinal electrophysiological measurements as tools to investigate the pathophysiology of MDD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychiatric Research - Volume 70, November 2015, Pages 113–120
نویسندگان
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