کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3280828 1589872 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum superoxide dismutase activity in acute and chronic paediatric liver diseases
ترجمه فارسی عنوان
فعالیت سوپراکسید دیسموتاز سرم در بیماری های کبدی حاد و مزمن کودکان
کلمات کلیدی
بیماری کبد، کلستاز پزشکی، استرس اکسیداتیو، کلستاز جراحی، سوکسوکس دیسموتاز
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Background and study aimsMeasuring serum superoxide dismutase (SOD) levels in infants and children having acute or chronic liver disease of different aetiologies, and correlating these levels with disease aetiology in an attempt to clarify the role of SOD as an antioxidant in these diseases.Patients and methodsWe prospectively enrolled 58 infants and children and divided them into four groups: Group I, 24 patients with surgical cholestasis; group II, 11 patients with medical cholestasis; group III, nine patients with autoimmune chronic hepatitis; and group IV, 14 patients with viral hepatitis. Forty healthy age- and sex-matched children served as controls. Serum SOD activity was measured in all patients and controls using spectrophotometry.ResultsThe level of SOD showed a statistically significant increase in patients with medical cholestasis compared to healthy controls (p < 0.0001). SOD activity of other groups showed no significant difference compared to controls.ConclusionsSignificantly increased serum SOD in infants and children with medical cholestasis is probably consequent to its increase in liver tissue in response to the liberation of reactive oxygen species. This suggests that products of free radical reactions might be involved in the pathogenesis and/or progression of medical cholestasis, and that SOD might attempt to minimise the liver injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Arab Journal of Gastroenterology - Volume 15, Issue 2, June 2014, Pages 72–75
نویسندگان
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