کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3281863 | 1209133 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Persistence of Human Papillomavirus, Overexpression of p53, and Outcomes of Patients After Endoscopic Ablation of Barrett's Esophagus
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کلمات کلیدی
IQRHR-HPVRFAISHCE-DCE-IMEMRNGSEACHGDLGDIn situ hybridization - Hybridization در محلFFPE - MEPCervical intraepithelial neoplasia - neoplasia intraepithelial گردن رحمEsophageal adenocarcinoma - آدنوکارسینوما مریGastroesophageal junction - اتصال مفاصل معدهIHC - ایمونوهیستوشیمیImmunohistochemistry - ایمونوهیستوشیمیEMR, endoscopic mucosal resection - برداشتن مخاط آندوسکوپیNext generation sequencing - توالی نسل بعدیGEJ - جی جیCin - جینradiofrequency ablation - حذف با بسامد رادیوییhigh-grade dysplasia - دیسپلازی درجه بالاlow-grade dysplasia - دیسپلازی کم درجهcomplete eradication of dysplasia - ریشه کن شدن کامل ریزش موی بینیcomplete eradication of intestinal metaplasia - ریشه کن کردن کامل متاپلازی رودهCarcinogenesis - سرطانزاییTumor suppressor - سرکوبگر تومورconfidence interval - فاصله اطمینانformalin-fixed paraffin-embedded - فرمالین ثابت پارافین تعبیه شده استinterquartile range - محدوده بین محدبBarrett’s esophagus - مری بارتHigh-risk human papillomavirus - ویروس پاپیلومای با خطر بالاGenetic - ژنتیک
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Persistence of Human Papillomavirus, Overexpression of p53, and Outcomes of Patients After Endoscopic Ablation of Barrett's Esophagus Persistence of Human Papillomavirus, Overexpression of p53, and Outcomes of Patients After Endoscopic Ablation of Barrett's Esophagus](/preview/png/3281863.png)
چکیده انگلیسی
We investigated the role of high-risk human papillomavirus (hr-HPV) in patients with Barrett's dysplasia and adenocarcinoma (EAC). Clearance vs persistence of HPV (DNA, E6 or E7 mRNA, and p16INK4A protein) and overexpression or mutation of p53 were determined for 40 patients who underwent endotherapy for Barrett's dysplasia or EAC. After ablation, dysplasia or neoplasia was eradicated in 34 subjects (24 squamous, 10 intestinal metaplasia). Six patients had detectable lesions after treatment; 2 were positive for transcriptionally active hr-HPV, and 4 had overexpression of p53. Before endotherapy, 15 patients had biologically active hr-HPV, 13 cleared the infection with treatment, and dysplasia or EAC was eliminated from 12 patients. One patient who cleared HPV after ablation acquired a p53 mutation, and their cancer progressed. Of 13 patients with overexpression of p53 before treatment, 10 cleared the p53 abnormality after ablation with eradication of dysplasia or neoplasia, whereas 3 of 13 had persistent p53 mutation-associated dysplasia after endotherapy (PÂ = .004). Immunohistochemical and sequence analyses of p53 produced concordant results for 36 of 40 samples (90%). Detection of dysplasia or neoplasia after treatment was associated with HPV persistence or continued p53 overexpression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 13, Issue 7, July 2015, Pages 1364-1368.e5
Journal: Clinical Gastroenterology and Hepatology - Volume 13, Issue 7, July 2015, Pages 1364-1368.e5
نویسندگان
Shanmugarajah Rajendra, Bin Wang, Darren Pavey, Prateek Sharma, Tao Yang, Cheok Soon Lee, Neil Gupta, Madeleine J. Ball, Raghubinder Singh Gill, Xiaojuan Wu,