کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285184 | 1209222 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of Prolonged Interferon Therapy on the Outcome of Hepatitis C Virus-Related Cirrhosis: A Randomized Trial
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کلمات کلیدی
ALTHCC - HCCα-fetoprotein - α-فتو پروتئینAlanine aminotransferase - آلانین آمینوترانسفرازinterferon - اینترفرونIFN - اینترفرون هاAFP - تست AFP یا آلفا فیتو پروتئینnot significant - مهم نیستHCV - هپاتیت سیHepatitis C virus - هپاتیت سیHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: The impact of interferon (IFN) treatment on the occurrence of complications related to hepatitis C virus (HCV)-related cirrhosis is debated because the majority of studies are retrospective. We designed a randomized controlled trial comparing the efficacy of prolonged IFN alfa-2a treatment vs nontreatment on complication-free survival in patients with compensated HCV cirrhosis. Methods: A total of 102 patients (mean age, 60.5 ± 9.5 y; male/female ratio, .82) with biopsy examination-proven HCV cirrhosis, Child-Pugh score A, who were hepatocellular carcinoma (HCC) free, and had at least 1 risk factor of complications were randomized to receive IFN or no therapy for 24 months. Results: During the follow-up evaluation, the complication rate was 24.5%: HCC occurred in 12 and decompensation unrelated to HCC occurred in 13 patients. The number of HCC patients was similar in both groups. The probability of complication-free survival was not significantly different between treated and untreated patients (98% and 72.3% vs 90% and 70.7% at 12 and 24 mo, respectively, P = .59). The median time until complication occurrence was 17.1 months in the treated group vs 13.6 months in the untreated group (P = .2). Conclusions: This randomized controlled trial showed that a 2-year course of IFN has little or no impact on complication-free survival in patients with high-risk compensated HCV cirrhosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 4, April 2007, Pages 502-507
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 4, April 2007, Pages 502-507
نویسندگان
Laetitia Fartoux, Françoise Degos, Christian Trépo, Odile Goria, Paul Calès, Albert Tran, Catherine Buffet, Thierry Poynard, Dominique Capron, Jean-Jacques Raabe, Dominique Roulot, Sylvie Naveau, Jean-Didier Grange, Renée E. Poupon, Raoul Poupon,