کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285404 | 1209228 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serotonin Synthesis and Uptake in Symptomatic Patients With Crohn's Disease in Remission
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
5-HTCDEISCDAIIBDIBSenterochromaffin - انتروکرومافینCrohn’s disease - بیماری کرونCrohn’s disease endoscopic index of severity - بیماری کرون بیماری آندوسکوپی شدتInflammatory bowel disease - بیماریهای التهابی رودهserotonin reuptake transporter - ترانسفر مجدد جذب سروتونینGastrointestinal - دستگاه گوارشSERT - سختSerotonin - سروتونینirritable bowel syndrome - سندروم روده تحریک پذیر، کولیت عصبیCrohn’s Disease Activity Index - شاخص فعالیت بیماری کرونpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازUlcerative colitis - کولیت اولسراتیو
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Symptoms resembling irritable bowel syndrome (IBS) are reported frequently in Crohn's disease (CD) patients in remission. Studies of the mucosal content of serotonin, which is a pivotal neurotransmitter in the gut, suggest that serotonin availability is altered in IBS patients. We aimed to study the role of serotonin in the generation of IBS-like symptoms in CD patients in remission. Methods: Ileal and colonic biopsy specimens were obtained from 20 CD patients in remission, 10 with and 10 without IBS-like symptoms, and 11 healthy controls. Enterochromaffin cells were counted, and messenger RNA expression levels of tryptophan hydroxylase (TpH)-1 and serotonin reuptake transporter were determined. Results: The levels of mucosal serotonin reuptake transporter expression were significantly higher in the ileum than in the colon, in all groups studied (P < .02). When the ileum and colon were analyzed separately, TpH-1 expression in the colon of CD patients with IBS-like symptoms was found to be significantly higher compared with the 2 other studied groups (controls, P < .005; CD patients without IBS-like symptoms, P < .01). The number of enterochromaffin cells per gland was comparable for the patient groups in the ileum and colon. Conclusions: CD patients in remission who experience IBS-like symptoms have increased mucosal TpH-1 levels in the colon, suggesting that increased serotonin biosynthesis in the colon plays a role in the generation of the symptoms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 6, June 2007, Pages 714-720
Journal: Clinical Gastroenterology and Hepatology - Volume 5, Issue 6, June 2007, Pages 714-720
نویسندگان
Itta M. Minderhoud, Bas Oldenburg, Marguerite E.I. Schipper, José J.M. ter Linde, Melvin Samsom,