کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285849 | 1209245 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pancreatic Cancer in Patients With Pancreatic Cystic Lesions: A Prospective Study in 197 Patients
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کلمات کلیدی
FNAMCTSIRIntraductal papillary mucinous neoplasm of the pancreasEUSIPMCIPMNMRCPEndoscopic retrograde cholangiopancreatography - cholangiopancreatography رتروگراد endoscopicMucinous cystadenoma - cystadenoma مزانشیمیFNA, Fine needle aspiration - آسپیراسیون سوزنی ظریف، بیوپسی آسپیراسیون magnetic resonance cholangiopancreatography - تشدید مغناطیسی cholangiopancreatographycomputed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایUltrasonography - سونوگرافی endoscopic ultrasonography - سونوگرافی آندوسکوپیconfidence interval - فاصله اطمینانstandardized incidence ratio - نسبت برابری استاندارد شدهERCP یا endoscopic retrograde cholangiopancreatography - کلانژیوگرافی آندوسکوپیک عقبگرد یا ایآرسیپی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: K-ras mutation is frequently detected in pancreatic juice of patients with pancreatic small cystic lesions, as well as those with pancreatic cancer. Those cystic lesions are often found by chance with modern radiologic imaging modalities. In this study, we prospectively examined the prognosis of patients with pancreatic cystic lesions, focusing on pancreatic cancer development. Methods: A total of 197 patients with pancreatic cystic lesions, 80 with intraductal papillary mucinous neoplasm (IPMN) and 117 with non-IPMN cysts, were followed up for 3.8 years on average. Blood tests and imaging diagnosis were performed twice a year. The observed incidence of pancreatic cancer was compared with the expected incidence calculated on the basis of age- and gender-matched mortality of pancreatic cancer in the general Japanese population. Results: Pancreatic cancer developed in 7 patients during the observation period (0.95% per year), infiltrating ductal carcinoma in 5 and intraductal papillary mucinous carcinoma in 2. Three of the ductal cancer cases had pancreatic non-IPMN cyst as preexisting lesion. At least 2 of the carcinomas arose in regions remote from preexisting lesions. The observed incidence of pancreatic cancer was 22.5 times higher (95% confidence interval, 11.0-45.3) than expected mortality from this cancer among general population. Conclusions: Patients with pancreatic cystic lesions are at a considerably high risk for pancreatic cancer, with a standardized incidence rate of 22.5. Cancer might develop in regions remote from the preexisting cystic lesion, suggesting diffuse pathologic changes predisposing to malignant transformation in the entire pancreas harboring cystic lesions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 10, October 2006, Pages 1265-1270
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 10, October 2006, Pages 1265-1270
نویسندگان
Minoru Tada, Takao Kawabe, Masatoshi Arizumi, Osamu Togawa, Saburo Matsubara, Natsuyo Yamamoto, Yosuke Nakai, Naoki Sasahira, Kenji Hirano, Takeshi Tsujino, Keisuke Tateishi, Hiroyuki Isayama, Nobuo Toda, Haruhiko Yoshida, Masao Omata,