کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3285918 | 1209248 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabolic and Adipokine Profile of Chinese Patients With Nonalcoholic Fatty Liver Disease
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کلمات کلیدی
IDFNAFLDHDLTNFATP IIIHOMA-IRWHRHbA1chigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاnonalcoholic steatohepatitis - استاتو هپاتیت غیر الکلیNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیInternational Diabetes Federation - دیابت بین المللی دیابتbody mass index - شاخص توده بدنBMI - شاخص توده بدنیtumor necrosis factor - فاکتور نکروز تومورLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)homeostasis model of insulin resistance - مدل هوموستاز از مقاومت انسولینNash - نوشGlycosylated hemoglobin - هموگلوبین گلیکوزیله شدهAdult Treatment Panel III - پنل درمان بزرگسالان III
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome are reaching epidemic levels worldwide, but data in Asia remain scarce. This cross-sectional study examined the metabolic and adipokine profiles of Chinese patients with biopsy-proven NAFLD and factors associated with severe disease. Methods: Eighty ethnic Chinese with NAFLD and 41 healthy controls were recruited. Metabolic parameters and fasting adiponectin, tumor necrosis factor-alpha (TNF-α), leptin, and resistin levels were measured on the day of liver biopsy. Histology was scored according to Brunt's criteria. Metabolic syndrome was assessed by using both the International Diabetes Federation and Adult Treatment Panel III criteria. Results: Twenty-eight patients had simple steatosis, and 52 patients had nonalcoholic steatohepatitis (NASH), defined as necroinflammatory grade â¥2 and/or fibrosis by Brunt's criteria. The ethnic-specific International Diabetes Federation criteria identified more cases of metabolic syndrome among NAFLD patients than the Adult Treatment Panel III criteria (70% vs 56%, P < .0001). On multivariate analysis, low adiponectin level, increased leptin level, and diabetes mellitus were associated with NAFLD. High TNF-α level and high body mass index were independent factors associated with NASH. TNF-α level had positive correlation with necroinflammatory grade (R = .35, P = .002) and fibrosis stage (R = .31, P = .005). Conclusions: Hypoadiponectinemia and elevated TNF-α levels are associated with the development of NAFLD and NASH, respectively, independent of other metabolic factors. Ethnic-specific definition of metabolic syndrome is more useful in the assessment of NAFLD patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 9, September 2006, Pages 1154-1161
Journal: Clinical Gastroenterology and Hepatology - Volume 4, Issue 9, September 2006, Pages 1154-1161
نویسندگان
Vincent Wai-Sun Wong, Alex Yui Hui, Steven Woon-Choy Tsang, Joyce Lai-Yee Chan, Ada Mei-Ling Tse, Kui-Fat Chan, Wing-Yee So, Angela Yuen-Shan Cheng, Wing-Fung Ng, Grace Lai-Hung Wong, Joseph Jao-Yiu Sung, Henry Lik-Yuen Chan,